Relationship of cow and calf circulating lipidomes with colostrum lipid composition and metabolic status of the cow

Newborn calves rely on lipids in colostrum for energy and immune function. The lipid concentration in colostrum, however, is highly variable, and little is known about its composition and maternal factors that influence its composition. The first objective was to measure plasma lipid composition of multiparous cows at 35 d before calving (BC; 35 ± 3 d; ± standard deviation) and 7 d BC (7 ± 2 d), their colostrum, and serum lipid composition of calves (24 h after birth) using multiple reaction monitoring profiling, which is an exploratory and highly sensitive lipidomic analysis method that screens lipids based on chemical functionality. Second, data were analyzed to determine if there were relationships between circulating lipids in the cow, colostrum lipids, and calf serum lipids. Third, relationships between markers of metabolic status of the cows and circulating and colostrum lipids were analyzed with correlation analysis. Blood was sampled and plasma prepared from multiparous cows (n = 16) at 35 and 7 d BC. Within 3 h of parturition, colostrum was collected from cows and fed to her calf. Calves received another feeding of colostrum within 12 h after birth and a serum sample was collected from each calf 24 h after the first feeding of colostrum. The metabolic status of cows was evaluated using insulin, glucose, and nonesterified fatty acid area under the curve in response to an intravenous glucose tolerance test performed at 3 wk BC. Lipids were extracted from plasma, colostrum, and calf serum and were analyzed using multiple reaction monitoring profiling. Concentration of lipids were calculated using spiked in standards and expressed as percent of lipids identified. Data were uploaded into MetaboAnalyst 5.0 for multivariate and univariate analysis. Principal component analysis indicated that circulating lipids in the cow and calf were distinct from lipids in colostrum. Phosphatidylglycerol (PG) concentration was greater in colostrum and calf serum than in cow plasma, with 23 of the 24 PG found in colostrum also found in calf serum. In response to intravenous glucose tolerance test in late gestation, nonesterified fatty acid area under the curve was positively related to total triacylglycerols lipids in 7 d BC plasma (r = 0.63) but negatively related to total membrane lipids in colostrum (r = ?0.55). Thus, the metabolic status of the dam influences circulating lipids and colostrum lipid content. Moreover, the circulating lipidome of the cow and calf are similar to one another and distinct from the colostrum lipidome, except for PG, where it appears that colostrum serves as the source for PG in the calf's circulation.     

我国MTBE的生产使用现状及趋势分析

对我国MTBE的生产工艺及下游产品进行了详细的分析,重点分析了影响MTBE产品生产使用的各方面因素,从能源方针、车用燃料政策及环保要求等角度对我国MTBE产品的未来发展趋势进行了预测分析。结果显示,2020年以后我国汽油调和用MTBE的生产使用量将逐步降低,但此过程可能会较为平缓。     

肉桂特色资源加工利用产业发展现状

肉桂是我国特色经济林树种，我国肉桂种植面积和年产量均居世界首位。我国肉桂主要分布在两广地区，其中广西为14.9万hm²，广东为8.9万hm²，两地面积占全国肉桂分布总面积的95%以上。肉桂既是著名的香料又是传统的名贵中药，具有极高的经济价值，发展肉桂产业对于促进农民增收、维护健康中国有着重要的意义。本研究综述了肉桂资源量、分布情况及主要利用部位，介绍肉桂主要产品（如桂皮，桂枝，肉桂粉及肉桂油）及加工技术现状、产品质量控制及其分析检测方法，分析了产业未来的发展趋势，并提出了产业发展的对策和措施：加强肉桂标准化示范基地建设，提高优质资源供给能力；提高肉桂加工利用技术水平，延长产业链；培育肉桂龙头企业，提高产品市场竞争力。为我国肉桂特色资源加工利用产业的可持续发展提供一定的思路。     

Milk from cows fed a diet with a high forage:concentrate ratio improves inflammatory state,oxidative stress,and mitochondrial function in rats

Excessive energy intake may evoke complex biochemical processes characterized by inflammation, oxidative stress, and impairment of mitochondrial function that represent the main factors underlying noncommunicable diseases. Because cow milk is widely used for human nutrition and in food industry processing, the nutritional quality of milk is of special interest with respect to human health. In our study, we analyzed milk produced by dairy cows fed a diet characterized by a high forage:concentrate ratio (high forage milk, HFM). In view of the low n-6:n-3 ratio and high content of conjugated linoleic acid of HFM, we studied the effects of this milk on lipid metabolism, inflammation, mitochondrial function, and oxidative stress in a rat model. To this end, we supplemented for 4 wk the diet of male Wistar rats with HFM and with an isocaloric amount (82 kJ, 22 mL/d) of milk obtained from cows fed a diet with low forage:concentrate ratio, and analyzed the metabolic parameters of the animals. Our results indicate that HFM may positively affect lipid metabolism, leptin:adiponectin ratio, inflammation, mitochondrial function, and oxidative stress, providing the first evidence of the beneficial effects of HFM on rat metabolism.     

基于物联网的重离子加速器状态诊断系统研究与设计

为更好地保障中国科学院近代物理研究所重离子加速器（HIRFL）的稳定运行，本文研究设计了基于物联网的状态诊断系统。针对HIRFL中设备数量庞大、种类复杂的特点，采用物联网的设计架构，利用各种传感器进行数据采集，并通过网络传输给中央控制系统中的数据库，由服务器中运行的控制软件对这些数据进行综合分析，给出合理的建议并发出相应的指令。根据HIRFL的实际情况，初步设计了1个HIRFL状态诊断系统模型，包括底层的硬件设计和上层的软件设计以及界面设计。部分控制界面已上线运行，并在实际运行中得到了检验，取得了一定的加速器状态诊断效果。     

高温车用燃料电池的发展及现状综述

燃料电池车以其能量转化效率高、绿色环保、噪音低等优点，被认为是替代传统化石能源汽车最有前景的新能源汽车。目前车用燃料电池的工作温度一般都低于80℃，低温的工作环境使其面临着诸多问题，如复杂的水管理和CO中毒等。通过提高质子交换膜燃料电池（PEMFC）的工作温度可以缓解这些问题，提高燃料电池的性能。然而，高温的工作环境也会对燃料电池带来诸多挑战，如膜脱水、催化剂团聚、冷启动速度缓慢等。要促进高温（90～120℃）车用燃料电池的快速发展，需要对其问题及解决方法进行分析。本文从电堆比功率、膜电极、双极板、进气方式、加湿方式等方面，介绍燃料电池的发展现状及存在的问题，包括Nafion膜和催化剂的热稳定问题、双极板的耐腐蚀问题、流道的气体分配问题、进气方式和加湿方式的优化以及冷启动问题。指出通过掺杂亲水性氧化物改善Nafion膜的高温性能；将Pt合金化及采用介孔炭提高催化剂的稳定性和电化学活性；镀层不锈钢金属双极板可以增强耐腐蚀性；3D流场等新型流场结构及提高进气温度、速度可以提高气体的均匀性；采用自增湿方式可以简化电堆结构等解决方法，以期对燃料电池车的进一步发展起到引导作用。     

中国无机盐工业发展现状及展望

建国70 a以来中国无机盐工业发展迅猛,取得了巨大成就,中国已成为世界上最大的无机盐生产、出口和消费国。分析了中国无机盐工业生产现状和进出口情况,指出行业存在大宗产品产能过剩、产品精细化率偏低、产业集中度和资源配置率偏低、矿产资源保障能力不足、节能减排任务重、自主创新能力弱等问题,并提出未来发展建议及发展方向。新能源用无机材料、无机粉体功能材料、5G通迅用无机材料、电子化学品和电镀化学品等专用化学品将是未来无机盐工业发展的热点。随着产业链现代化水平的不断提升,将会逐渐实现行业规模化、绿色发展与安全生产。